Brief History

Key Publications & Discoveries

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Discovery of the DNA Flap sequence.
2006 A single immunization with a minute dose of a lentiviral vector-based vaccine is highly effective at eliciting protective humoral immunity against West Nile virus. Iglesias et al. J. Gene Med. 8: 265–274.
2007 HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore. Arhel et al. EMBO J. 2007 Jun 20;26(12):3025-37.
2007 Lentiviral vectors encoding HIV-1 polyepitopes induce broad CTL responses in vivo. Iglesias et al. Molecular Therapy; Volume 15; Issue 6; 1203 - 1210.
2008 Protective antiviral immunity conferred by a nonintegrative lentiviral vector-based vaccine. Coutant et al. PLOS ONE 3(12): e3973.
2009 Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques. Beignon et al. Journal of Virology; 83(21); 10963–10974.
2010 Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo. Adotévi et al. 
2010 Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice. Rusakiewicz et al. Vaccine; Volume 28; Issue 38; 2010; Pages 6374-6381; ISSN 0264-410X.
2011 Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis. Calderón-Gómez et al. Eur. J. Immunol. 41: 1696–1708.
2011 Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection. Iglesias et al. Retrovirology; 2011 Nov 10;8:92. 
2012 HIV-derived vectors for therapy and vaccination against HIV. Di Nunzio et al. Vaccine; Volume 30; Issue 15; 2012; Pages 2499-2509; ISSN 0264-410X.
2012 A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria. Coutant et al.  PLOS ONE 7(11): e48644.
2015 A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigsde Wispelaere et al. PLOS Neglected Tropical Diseases 9(10): e0004081. 
2017 A Japanese Encephalitis virus vaccine inducing antibodies strongly enhancing in vitro infection is protective in pigs. García-Nicolás et al. Viruses 2017; 9(5); 124.