Brief History

Key Publications & Discoveries

MedicalRF_GettyImages_HIV_slider
1998 Discovery of the DNA Flap sequence.
2007 HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore.
2008 Protective antiviral immunity conferred by a nonintegrative lentiviral vector-based vaccine.
2009 Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques.
2010 Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo.
2010 Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice.
2011 Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection.
2012 A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria
2015 A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs.