A major scientific publication

Development of an onco-therapeutic vaccine candidate against human papillomavirus (HPV)-induced cancers, based on preclinical results showing 100% efficacy

The Biotech TheraVectys, in collaboration with Institut Pasteur-TheraVectys Joint Laboratory, has just demonstrated the preclinical efficacy of its “Lenti-HPV-07” lentiviral vector-based vaccine candidate, administered intramuscularly, against cervical and oropharyngeal cancers induced by human papillomavirus (HPV).

“ Our vaccine candidate induces a 100% tumor eradication in our preclinical model and a long-term memory immune response that prevents the risk of tumor relapse. This technological advance enables us to expect a major clinical benefit in the treatment of HPV cancer, and offers very promising prospects for other tumor indications. These results are far superior to those obtained in the same pre-clinical model by other vaccine technologies, notably mRNA “.
Pierre Charneau, CSO of TheraVectys

These results were published in EMBO Molecular Medicine journal on September 7, 2023, in an article entitled “Full eradication of pre-clinical human papilloma virusinduced tumors by a lentiviral vaccine”.

Pierre Charneau answers questions from the journalist Alexandra Delbot on radiofrance.fr

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